Association between Apolipoprotein L1 genetic variants and risk of preeclampsia and preterm birth among U.S. Black women.

ABSTRACT:

Background

Preeclampsia and preterm birth disproportionally affects Black women, but the current understanding of genetic predisposition to preeclampsia and preterm birth is rudimentary. It has been hypothesized that carriers of high-risk genetic variants in the apolipoprotein L1 gene (APOL1) may have an increased risk of preeclampsia and preterm birth. These genetic variants are found only among individuals of recent African ancestry. Previous studies have been small and have yielded inconsistent results.

Objective

To examine whether APOL1 genetic variants are associated with risk of preeclampsia or preterm birth.

Study design

We conducted a retrospective case-control study of 6616 Black women from the Black Women's Health Study, a cohort of self-identi

SUBMITTER: Sheehy S 

PROVIDER: S-EPMC11783058 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature