Olfactory and Gustatory Disturbances as Early Indicators of Lung Cancer in Patients with Sleep Disorders: A Retrospective Cohort Study from the TriNetX US Collaborative Networks.

ABSTRACT: Background: Olfactory and gustatory disturbances are commonly overlooked symptoms but may be linked to various health conditions, including cancer. Emerging evidence suggests that these sensory impairments could be early indicators of lung cancer, particularly in individuals with sleep disorders, a group already at elevated cancer risk due to factors like circadian disruption and hormonal changes. Objective: To evaluate whether olfactory and gustatory disturbances can serve as early markers for lung cancer in patients with sleep disorders. Methods: A retrospective cohort study was performed using data from the TriNetX database, spanning January 1, 2016, to June 30, 2024. Propensity score matching (1:1) was used to balance baseline characteristics between patients with

SUBMITTER: Tsai RY 

PROVIDER: S-EPMC11783070 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature