Elevated Serum TSH Levels and TPOAb Positivity in Early Pregnancy are Associated with Increased Risk of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study.

ABSTRACT: Background: The relationship between maternal thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) status and hypertensive disorders of pregnancy (HDP) remains uncertain. Methods: This was a prospective cohort study based on the China Birth Cohort Study (CBCS). 36,256 women were included at 6 to 13⁺⁶ gestation from February 2018 to December 2020. Generalized linear mixed models were used to investigate the association between thyroid function and HDP/BP. We further performed multiple subgroup analyses to test the robustness of this association. Results: The final study population was 25,608, and the overall incidence of HDP was 8.0%. After adjusting for maternal age, pre-pregnancy BMI, education, household annual in

SUBMITTER: Hu M 

PROVIDER: S-EPMC11783071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature