Detection of multiple signet ring cell carcinomas using texture and color enhancement imaging led to a diagnosis of hereditary diffuse gastric cancer.

ABSTRACT: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer caused by CDH1 mutation. HDGC causes multiple signet ring cell carcinomas (SRCCs) throughout the stomach. Few reports exist on the endoscopic findings during screening endoscopy, leading to the diagnosis of HDGC in its early stages. Recently, a new image-enhancement endoscopy technique, texture and color enhancement imaging (TXI), has been developed to improve the visibility of early gastric cancer. To the best of our knowledge, the use of TXI leading to HDGC diagnosis has not been reported. In this report, TXI contributed to the diagnosis of HDGC, and the patient was treated with total gastrectomy. A 27-year-old woman with a family history of gastric cancer underwent esophagogastroduodenoscopy, which revealed

SUBMITTER: Yamamoto J 

PROVIDER: S-EPMC11783146 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature