Immune checkpoint inhibitor infusion times and clinical outcomes in patients with melanoma.

ABSTRACT:

Background

Circadian rhythms impact immune function; a previous study demonstrated that immunotherapy treatment times taking place later in the day correlated with poorer outcomes in patients with melanoma. However, this finding has not been replicated, and other infusion timing schemas are unexplored. The objective of this retrospective, cohort study was to determine if the time of immunotherapy infusion affects outcomes.

Materials and methods

Five hundred and sixteen participants age ≥18 years diagnosed with cutaneous, acral, mucosal, or unknown primary melanoma treated with >1 infusion of nivolumab, pembrolizumab, or combination ipilimumab/PD-1 inhibitors were included. Response rate, toxicity rate, overall survival (OS), and progression-free survival (PFS) were determine

SUBMITTER: Fletcher K 

PROVIDER: S-EPMC11783311 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature