Bayesian gene set benchmark dose estimation for "omic" responses.

ABSTRACT:

Motivation

Estimating a toxic reference point using tools like the benchmark dose (BMD) is a critical step in setting policy to regulate pollution and ensure safe environments. Toxicity can be measured for different endpoints, including changes in gene expression and histopathology for various tissues, and is typically explored one gene or tissue at a time in a univariate setting that ignores correlation. In this work, we develop a multivariate estimation procedure to estimate the BMD for specified gene sets. Our approach extends the foundational univariate approach by accounting for correlation in a statistically principled way.

Results

We illustrate the method using data from a 5-day rat study and Hallmark gene sets and compare to existing BMD results computed by the EPA f

SUBMITTER: Zilber D 

PROVIDER: S-EPMC11783320 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature