Causal relationships between hippocampal volumetric traits and the risk of Alzheimer's disease: a Mendelian randomization study.

ABSTRACT: Alzheimer's disease, a common and progressive neurodegenerative disorder, is associated with alterations in hippocampal volume, as revealed by neuroimaging research. However, the causal links between the volumes of the hippocampus and its subfield structures with Alzheimer's disease remain unknown. A genetic correlation analysis using linkage disequilibrium score regression was conducted to identify hippocampal volumetric traits linked to Alzheimer's disease. Following this, to examine the causal links between Alzheimer's disease and hippocampal volumetric traits, we applied a two-sample Mendelian randomization approach, utilizing a bidirectional framework. Seven hippocampal volumetric traits were found as genetically correlated with Alzheimer's disease in the genetic correlation analysis

SUBMITTER: Guo L 

PROVIDER: S-EPMC11783321 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature