Effects of collagen and chondroitin sulfate on relaxation at multiple magnetic field strengths.

ABSTRACT:

Purpose

To elucidate the connection between MRI relaxation properties of articular cartilage and tissue composition, in terms of collagen and chondroitin sulfate (CS). Additional aims were to determine the effect of different magnetic field strengths, as well as the effect of concentrations of the components on relaxation properties.

Methods

A series of MRI phantoms consisting of gels containing collagen and chondroitin sulfate were prepared with final concentrations of collagen in the range 20-60 mg/g and the CS concentration in the range 0-40 mg/g. R1 (= 1/ T1 ) and R2 (= 1/ T2 ) values of the phantoms were measured at three different MRI field strengths (1.5, 3.0 and 9.4 T), R1ρ (= 1/ T1ρ ) values were measured at 9.4 T.

Results

Relaxation rates generally increased

SUBMITTER: Aro OP 

PROVIDER: S-EPMC11783438 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature