Different behaviour of target-controlled infusion pumps despite apparently using the same Schnider pharmacokinetic model: An observational in vitro study.

ABSTRACT:

Background

Target-controlled infusion (TCI) pumps deliver an initial bolus of drug to achieve a preset drug target concentration quickly.

Objective

We investigated whether differences exist in the initial bolus dose between different TCI pumps despite apparently using the same pharmacokinetic (PK) model.

Design

Observational study.

Setting

Laboratory data from a German University Hospital. Experiments were performed between February 2019 and September 2020.

Participants

Four TCI pumps set to the Schnider model in effect-site mode with a target propofol concentration of 3.5 μg ml^-1 were studied. The algorithms of two pumps employed a fixed equilibration rate constant (k _e0) of 0.456 min^-1 (Perfusor® Space® and Injec

SUBMITTER: Soehle M 

PROVIDER: S-EPMC11783638 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature