Olfactory Dysfunction in Primary Ciliary Dyskinesia.

ABSTRACT:

Objective

Individuals with primary ciliary dyskinesia (PCD) frequently report olfactory dysfunction, yet this deficit is poorly documented. The purpose of this study was to characterize the presence and degree of olfactory dysfunction in PCD compared to controls and determine whether certain PCD genes are associated with worse olfaction.

Study design

A prospective cohort study.

Setting

Tertiary referral center.

Methods

We administered the University of Pennsylvania Smell Identification Test (UPSIT) to individuals with PCD. Participants were divided into 3 age groups (15-29 years, 30-44 years, and 45+ years) and compared to age- and sex-matched normal controls (n = 2170).

Results

Twenty-nine individuals with PCD (8 males and 21 females) met the criteria (

SUBMITTER: Farzal Z 

PROVIDER: S-EPMC11783683 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature