Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA.

ABSTRACT:

Background

The widespread use of bisphenol A (BPA) has led to universal exposure among the population, raising concerns about its health effects. Epidemiological studies have linked environmentally relevant levels of BPA exposure to obesity.

Objectives

We aimed to uncover the complex mechanisms by which oral exposure during pregnancy with BPA affects the offspring.

Methods

We conducted a two-stage mouse study. In stage 1, we gavaged dams with BPA at 0.05, 0.5, and 5mg/kg per day during pregnancy, and we tracked the offspring's weight and diet to 12 wk of age. In stage 2, exosomes from BPA-exposed dams and offspring were injected into pregnant mice and 3-wk-old males, respectively, and the mice were observed up to 12 wk. We then sequenced exosomal microRNAs (miRNAs) in

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11783688 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature