Identification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study.

ABSTRACT:

Objective

This study aims to identify potential lipid biomarkers and metabolic pathways associated with oral cancer (OC). Then to establish and evaluate disease classification models capable of distinguishing OC patients from healthy controls.

Methods

A total of 41 OC patients and 41 controls were recruited from a hospital in Southeast China to examine the serum lipidomics by Ultra-high Performance Liquid Chromatography Q Exactive Mass Spectrometry (UHPLC-QE-MS).

Results

The total serum lipid profile showed that triglycerides accounted for the highest proportion of total metabolites, reaching 35.90% of the total. A total of 74 different metabolites were screened (12 up-regulated and 62 down-regulated), mainly enriched in the glycerophospholipid metabolism pathway. The

SUBMITTER: Wang N 

PROVIDER: S-EPMC11783747 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature