Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study.

ABSTRACT:

Background

The Anticholinergic Risk Scale and Total Anticholinergic Load were developed to assess the risks associated with anticholinergic drugs. Recently, the Japan Anticholinergic Risk Scale was introduced; however, the total anticholinergic load for adverse events has not been clarified, and the criteria for risk assessment in clinical practice have not been established. In this study, we used data from the Japanese Adverse Drug Event Report (JADER) database provided by the Pharmaceuticals and Medical Devices Agency to determine the total anticholinergic load associated with reported adverse events related to anticholinergic syndrome.

Methods

Using JADER data from April 2004 to September 2023, we investigated the association between drugs included in the J-ARS and advers

SUBMITTER: Kan Y 

PROVIDER: S-EPMC11783805 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature