HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients.

ABSTRACT:

Background

SARS-CoV-2 infection affects both lipid metabolism and lung function. The severity of the disease has been associated with reduced levels of both high-density lipoprotein (HDL) and low-density lipoprotein cholesterol. Despite the crucial role that these nanoparticles play in SARS-CoV-2 infection, few studies have examined their structure during COVID-19 beyond HDL quantity. The study aimed to assess apolipoprotein levels in COVID-19 patients who either survived or died following ICU admission. In addition, ICU survivors and non-survivors were compared for HDL particle size and proteome.

Methods

Between February and April 2020, our study enrolled 37 COVID-19 patients upon their intensive care unit admission. Among them, 18 survived the disease, while 19 succumbed t

SUBMITTER: Begue F 

PROVIDER: S-EPMC11783863 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature