Functional evolution and diversification of CYP82D subfamily members have shaped flavonoid diversification in the genus Scutellaria.

ABSTRACT: Flavonoids, the largest class of polyphenols, exhibit substantial structural and functional diversity, yet their evolutionary diversification and specialized functions remain largely unexplored. The genus Scutellaria is notable for its rich flavonoid diversity, particularly of 6/8-hydroxylated variants biosynthesized by the cytochrome P450 subfamily CYP82D. Our study analyzes metabolic differences between Scutellaria baicalensis and Scutellaria barbata, and the results suggest that CYP82Ds have acquired a broad range of catalytic functions over their evolution. By integrating analyses of metabolic networks and gene evolution across 22 Scutellaria species, we rapidly identified 261 flavonoids and delineated five clades of CYP82Ds associated with various catalytic functions. This approach re

SUBMITTER: Qiu S 

PROVIDER: S-EPMC11783885 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature