Infiltration and subtype analysis of CD3 + CD20 + T cells in lung cancer.

ABSTRACT:

Background

CD3 + CD20 + T cells (T_B cells) are a subset of lymphocytes in the human body that are associated with inflammation. They originate from T cells interacting with B cells, and their levels are abnormally elevated in individuals with immune disorders, as well as in some cancer patients. The interplay between tumor immunity and inflammation is intricate, yet the specific involvement of T_B cells in local tumor immunity remains uncertain, with limited research on their subtypes.

Methods

Lung cancer surgical samples were stained using multi-color immunofluorescence to study the subtypes and distribution patterns of T_B cells.

Results

T_B cells were confirmed to exist in a scattered pattern within tertiary lymphoid structu

SUBMITTER: Luo L 

PROVIDER: S-EPMC11783900 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature