Nitrogen-containing bisphosphonate for vascular calcification: animal experiments, systematic review and meta-analysis.

ABSTRACT:

Background

The purpose of our study was to explore the effect of nitrogen-containing bisphosphonate (N-BP) on vascular calcification (VC) through animal experiments and a meta-analysis.

Methods

In our animal experiments, Sprague-Dawley (SD) rats were randomly divided into a control group, a VC group, a low-dose zoledronic acid (ZOL) (20 µg/kg) group and a high-dose ZOL (100 µg/kg) group. The calcification of the aortic arch was observed by alizarin red staining. The calcium content of the aortic arch was measured. In our systematic review and meta-analysis, databases, including PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), and the Wanfang database, were searched from their inception to December 20, 2023. Eligible studies comparing N-BP

SUBMITTER: Xu W 

PROVIDER: S-EPMC11783937 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature