Balanced crystalloid versus saline for resuscitation in pediatric septic shock: a systematic review and meta-analysis.

ABSTRACT:

Background

Fluid resuscitation is a cornerstone of septic shock management in pediatric patients, with normal saline (NS) being the traditional choice. However, balanced solutions (BS) have gained attention due to their potential to mitigate acid-base and electrolyte disturbances. Despite this, the optimal choice between BS and NS for pediatric sepsis remains unclear. Therefore, we aimed to conduct a meta-analysis comparing the clinical outcomes of BS versus NS in pediatric patients with sepsis.

Methods

We systematically searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials, along with reference lists of retrieved publications, for studies comparing clinical outcomes in pediatric patients with sepsis treated with BS versus NS. Our outcomes of interest i

SUBMITTER: Vijendra B 

PROVIDER: S-EPMC11783956 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature