Clinical integration of germline findings from a tumor testing precision medicine program.

ABSTRACT:

Background

Integrating germline genetic testing (GGT) recommendations from tumor testing into hereditary cancer clinics and precision oncology trials presents challenges that require multidisciplinary expertise and infrastructure. While there have been advancements in standardizing molecular tumor boards, the implementation of tumor profiling for germline-focused assessments has only recently gained momentum. However, this progress remains inconsistent across institutions, largely owing to a lack of systematic approaches for managing these findings. This study outlines the development of a clinical pathway for identifying potential germline variants from an institutional tumor-sequencing research program at Princess Margaret Cancer Centre.

Methods

Between August 2022 and Aug

SUBMITTER: Sanabria-Salas MC 

PROVIDER: S-EPMC11783960 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature