Characteristics of genomic alterations and heavy metals in hypertensive patients with non‑small cell lung cancer.

ABSTRACT: Both lung cancer and cardiovascular disease (CVD) are prevalent diseases that contribute to global mortality rates. Although individuals with CVD may face an elevated risk of cancer based on the presence of shared risk factors (such as tobacco smoking and excessive body weight), the roles of somatic mutations and heavy metal distributions remain unknown. The present study aimed to explore the differences in somatic mutations and heavy metal distributions between hypertensive patients and non-hypertensive patients in a cohort of patients with non-small cell lung cancer (NSCLC). Tumor tissue samples from 64 patients were analyzed using a next-generation sequencing panel consisting of 82 tumor-related genes through hybrid capture. Serum samples were also analyzed to determine the levels of 18

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11783997 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature