Adaptive evolution of extensive drug resistance and persistence in epidemic ST11 KPC-producing <i>Klebsiella pneumoniae</i> during antimicrobial chemotherapy.

ABSTRACT: The global rise of carbapenem-resistant Klebsiella pneumoniae, including strains producing K. pneumoniae carbapenemase (KPC) types, poses a significant public health challenge due to their resistance to critical antibiotics. Treatment options for infections caused by KPC-producing K. pneumoniae (KPC-KP) are increasingly limited, particularly as these strains develop resistance to last-line antibiotics such as ceftazidime/avibactam and colistin. This study investigates the evolution of antibiotic resistance and persistence in a series of clonally related ST11 KPC-KP strains isolated from a single patient undergoing extended antimicrobial treatment. The patient, a 47-year-old male with a history of kidney transplantation, developed multiple KPC-KP lung infections during

SUBMITTER: Li T 

PROVIDER: S-EPMC11784014 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature