Transcriptional delineation of polysaccharide utilization loci in the human gut commensal <i>Segatella copri</i> DSM18205 and co-culture with exemplar <i>Bacteroides</i> species on dietary plant glycans.

ABSTRACT: There is growing interest in members of the genus Segatella (family Prevotellaceae) as members of a well-balanced human gut microbiota (HGM). Segatella are particularly associated with the consumption of a diet rich in plant polysaccharides comprising dietary fiber. However, understanding of the molecular basis of complex carbohydrate utilization in Segatella species is currently incomplete. Here, we used RNA sequencing (RNA-seq) of the type strain Segatella copri DSM 18205 (previously Prevotella copri CB7) to define precisely individual polysaccharide utilization loci (PULs) and associated carbohydrate-active enzymes (CAZymes) that are implicated in the catabolism of common fruit, vegetable, and grain polysaccharides (viz. mixed-linkage β-g

SUBMITTER: Panwar D 

PROVIDER: S-EPMC11784079 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature