Characterization and genomic analysis of the highly virulent <i>Acinetobacter baumannii</i> ST1791 strain dominating in Anhui, China.

ABSTRACT: The multidrug-resistant Acinetobacter baumannii clonal complex 92 is spreading worldwide due to its high-frequency gene mutation and recombination, posing a significant threat to global medical and health safety. Between November 2021 and April 2022, a total of 132 clinical A. baumannii isolates were collected from a tertiary hospital in China. Their growth ability and virulence of these isolates were assessed using growth curve analyses and the Galleria mellonella infection model. The genetic characteristics of the isolates were further examined through whole-genome sequencing. ST1791^O/ST2^P isolates represented the largest proportion of isolates in our collection and exhibited the highest growth rate and strongest virulence among all sequence typ

SUBMITTER: He Z 

PROVIDER: S-EPMC11784083 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature