Ferruginous hemeprotein HhuH facilitates the cadmium adsorption and chromium reduction in <i>Stenotrophomonas</i> sp. SY1.

ABSTRACT: Cadmium (Cd) and chromium (Cr) are frequently encountered toxicants, while iron (Fe) plays a crucial role in bacterial survival under conditions of heavy metal stress. However, intracellular Fe ion depletion by heavy metals leads to a state of Fe starvation. Therefore, it is imperative to investigate the mechanism through which bacteria maintain a balance between heavy metal detoxification and Fe homeostasis. This study demonstrates Cd(II) immobilization and Cr(VI) reduction abilities of Stenotrophomonas sp. SY1, while proteomics reveals the upregulation of heme metabolism in response to Cd(II) and Cr(VI) exposure. The expression of the heme-uptake system in Escherichia coli can enhance Cd(II) immobilization and facilitate Cr(VI) reduction. The ferruginous hemeprotein HhuH ex

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11784086 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature