The BfmRS stress response protects <i>Acinetobacter baumannii</i> against defects in outer membrane lipoprotein biogenesis.

ABSTRACT: The outer membrane (OM) of Gram-negative bacteria is the outermost layer of the cell and serves as permeability barrier against environmental toxins, including antibiotics. The OM is built by several pathways that transport and assemble lipids and proteins into the OM. Since the OM is an essential organelle for the cell, envelope stress responses (ESRs) continuously monitor its assembly to preserve viability if defects arise. While ESRs have been extensively characterized in Escherichia coli, they are generally narrowly conserved. Lipoprotein trafficking to the OM via the "Lol" pathway is a linchpin for all OM assembly pathways. In E. coli, defects in this essential process are sensed when the sensor OM lipoprotein NlpE activates the CpxAR two-component system. Distantly rela

SUBMITTER: Marotta J 

PROVIDER: S-EPMC11784087 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature