CD6 regulates CD4 T follicular helper cell differentiation and humoral immunity during murine coronavirus infection.

ABSTRACT: During activation, the T cell transmembrane receptor CD6 becomes incorporated into the T cell immunological synapse where it can exert both co-stimulatory and co-inhibitory functions. Given the ability of CD6 to carry out opposing functions, this study sought to determine how CD6 regulates early T cell activation in response to viral infection. Infection of CD6-deficient mice with a neurotropic murine coronavirus resulted in greater activation and expansion of CD4 T cells in the draining lymph nodes. Further analysis demonstrated that there was also preferential differentiation of CD4 T cells into T follicular helper cells, resulting in accelerated germinal center responses and emergence of high-affinity virus-specific antibodies. Given that CD6 conversely supports CD4 T cell activation in

SUBMITTER: Cardani-Boulton A 

PROVIDER: S-EPMC11784103 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature