Comparative evaluation of funduscopy, PCR and serology in the diagnosis of ocular toxoplasmosis at ECWA Eye Hospital, Kano.

ABSTRACT:

Objective

Ocular toxoplasmosis, caused by Toxoplasma gondii, is a significant cause of posterior uveitis and vision impairment globally. Accurate diagnosis is essential to prevent retinal damage and optimise treatment. This study aimed to compare three diagnostic methods funduscopy, serology (ELISA), and PCR in detecting ocular toxoplasmosis in patients at ECWA Eye Hospital, Kano, Nigeria.

Methods and analysis

A total of 264 patients suspected of having ocular toxoplasmosis were enrolled. Funduscopy was performed to identify retinal lesions typical of T. gondii. Serological analysis was conducted using ELISA to detect anti-Toxoplasma IgG antibodies. Additionally, PCR was used to confirm the presence of T. gondii DNA in blood samples. The results f

SUBMITTER: Adebakin BB 

PROVIDER: S-EPMC11784108 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature