Adherence to tuberculosis (TB) treatment in high compared to low TB burden countries: study protocol for a systematic review and meta-analysis with a qualitative meta-synthesis of themes.

ABSTRACT:

Introduction

Non-adherence to tuberculosis (TB) treatment poses a significant challenge to effective TB management globally and is a major contributor to the emergence of multidrug-resistant TB. Although adherence to TB treatment has been widely studied, a comprehensive evaluation of the comparative levels of adherence in high- versus low-TB burden settings remains lacking. The objective of this systematic review and meta-analysis is to assess the levels of adherence to TB treatment in high-TB burden countries compared to low-burden countries. Additionally, it seeks to identify the unique facilitators and barriers to treatment adherence in these distinct settings.

Methods and analysis

This systematic review and meta-analysis will be conducted in accordance with the Preferred

SUBMITTER: Eyawo O 

PROVIDER: S-EPMC11784167 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature