LC-AMP-I1, a novel venom-derived antimicrobial peptide from the wolf spider <i>Lycosa coelestis</i>.

ABSTRACT: Antibiotic resistance has become a critical concern in recent years, and antimicrobial peptides may function as innovative antibacterial agents to address this issue. In this work, we identified a novel antimicrobial peptide, LC-AMP-I1, derived from the venom of Lycosa coelestis, demonstrating substantial antibacterial properties and minimal hemolytic activity. LC-AMP-I1 was subjected to additional assessment for antibacterial efficacy, anti-biofilm properties, drug resistance, stability, and cytotoxicity in vitro. It exhibited comparable antibacterial efficacy to melittin against six common clinical multidrug-resistant bacteria, effectively inhibiting biofilm formation and disrupting established biofilms. Additionally, LC-AMP-I1 demonstrated minimal bacterial resistance, exc

SUBMITTER: Wang J 

PROVIDER: S-EPMC11784185 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature