RhlR-mediated cooperation in cystic fibrosis-adapted isolates of <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Pseudomonas aeruginosa uses quorum sensing (QS) to regulate the expression of dozens of genes, many of which encode shared products, called "public goods." P. aeruginosa possesses two complete acyl-homoserine lactone (AHL) QS circuits: the LasR-I and RhlR-I systems. Canonically, these systems are hierarchically organized: RhlR-I activity depends on LasR-I activation. However, in contrast to laboratory strains, isolates from people with cystic fibrosis can engage in AHL QS using only the transcription factor RhlR. In these isolates, RhlR regulates AHL QS and the production of secreted public goods, such as the exoprotease elastase, which are accessible to both producing and non-producing cells. When P. aeruginosa strains that use LasR to regulate elastase production are

SUBMITTER: Cruz RL 

PROVIDER: S-EPMC11784195 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature