Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex.

ABSTRACT: Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also disrupt astrocytes, which modulate neurovascular coupling-a process that regulates cerebral hemodynamics in response to neuronal activation. However, separating neuronal and astrocytic effects from cocaine's direct vasoactive effects has been challenging, partially due to limitations of neuroimaging techniques able to differentiate vascular from neuronal and glial effects at high temporal and spatial resolutions. Here, we used a newly-developed multi-channel fluorescence and optical coherence Doppler microscope (fl-ODM) that allows for simultaneous measurements of neuronal and astrocytic activities (reflected by the intracellular calcium changes in neurons Ca²⁺_N and astrocytes

SUBMITTER: Du C 

PROVIDER: S-EPMC11784220 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature