Multispecies emergence of dual <i>bla</i>_KPC/NDM carbapenemase-producing Enterobacterales recovered from invasive infections in Chile.

ABSTRACT: Carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) represent a significant global threat. The emergence of dual CP-CRE is particularly alarming, as they can potentially compromise the efficacy of newer antibiotics, further decreasing therapeutic alternatives. Herein, we report the emergence of multiple species of CP-CRE recovered from invasive infections in Chile that simultaneously harbor bla_KPC and bla_NDM and provide an in-depth genomic characterization of these worrisome pathogens. We collected carbapenem-resistant Enterobacterales (CRE) isolates from invasive infections over a 4-year period, across 11 healthcare centers in Chile. Bacterial species and the presence of carbapenemase genes were confirmed using MALDI-TOF and PCR assay

SUBMITTER: Quesille-Villalobos AM 

PROVIDER: S-EPMC11784225 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature