Protocol for a systematic review and individual participant data meta-analysis for risk factors for lung cancer in individuals with lung nodules identified by low-dose CT screening.

ABSTRACT:

Background

Worldwide, lung cancer (LC) is the second most frequent cancer and the leading cause of cancer related mortality. Low-dose CT (LDCT) screening reduced LC mortality by 20-24% in randomised trials of high-risk populations. A significant proportion of those screened have nodules detected that are found to be benign. Consequently, many individuals receive extra imaging and/or unnecessary procedures, which can have a negative physical and psychological impact, as well as placing a financial burden on health systems. Therefore, there is a need to identify individuals who need no interval CT between screening rounds.

Methods and analysis

The aim of this study is to identify risk factors predictive of LC, which are known at the time of the scan, in patients with LDCT scre

SUBMITTER: Alexandris P 

PROVIDER: S-EPMC11784322 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature