Risk of renal complications and death in young and middle-aged Swedes with parental type 1 diabetes: a nation-wide, prospective cohort study.

ABSTRACT:

Introduction

This study aimed to investigate if individuals with childhood-onset type 1 diabetes having a parent with the same condition (parental diabetes) had worse metabolic control and an increased risk of death and renal failure compared with those with parents without type 1 diabetes (sporadic diabetes).

Research design and methods

We conducted a population-based cohort study using data from the Swedish Childhood Diabetes Register, including cases with onset of type 1 diabetes before the age of 15 and recorded between 1977 and 2010. The cohort was linked to national registers to compare mortality, renal failure, and glycated hemoglobin (HBA1c) levels.

Results

We identified 16 572 incident cases of childhood-onset type 1 diabetes. Of these, 15 701 had data on par

SUBMITTER: Fredriksson M 

PROVIDER: S-EPMC11784379 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature