Protocol for a randomised 'screen-and-treat' <i>Helicobacter pylori</i> eradication trial in 14-18-years-old adolescents residing in three regions of Chile: effectiveness and microbiological host implications.

ABSTRACT:

Introduction

Gastric cancer is a major global health concern, being the final stage of a long-term process, primarily associated with Helicobacter pylori (H. pylori) infection. Early childhood acquisition of H. pylori with low spontaneous eradication rates underscores the need for preventive measures. Our previous pilot treatment study revealed high eradication rates, favourable tolerance profile and a decline in serum biomarkers indicative of gastric damage in asymptomatic school-aged children. The purpose of this study is to determine the potential benefit of a 'screen-and-treat' strategy targeting persistently infected, asymptomatic adolescents. Specific aims are to assess eradication efficacy, its clinical and molecular outcomes and potential clinical and m

SUBMITTER: George S 

PROVIDER: S-EPMC11784427 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature