Outcomes of patients treated with chemotherapy for breast cancer during pregnancy compared with nonpregnant breast cancer patients treated with systemic therapy.

ABSTRACT:

Introduction

Prior studies of patients treated for breast cancer during pregnancy (PrBC) report mixed outcomes and are limited by substandard treatment, small cohorts, and short follow-up. This study compared survival outcomes of PrBC patients treated with chemotherapy during pregnancy with nonpregnant patients matched by age, year of diagnosis, stage, and subtype.

Methods

PrBC patients treated from 1989 to 2022 on prospective institutional protocols were eligible. Disease-free survival (DFS), overall survival (OS), and progression-free survival (PFS) were estimated using the Kaplan-Meier method and multivariable Cox proportional hazards regression.

Results

Among 143 PrBC and 285 nonpregnant patients, median follow-up was 11.4 years. Survival differences were statisti

SUBMITTER: Johnson HM 

PROVIDER: S-EPMC11784491 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature