Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma.

ABSTRACT:

Background

Eosinophils are crucial in allergic inflammation, and their correlation with asthma severity has made them a focal point in predicting treatment outcomes. Blood eosinophil count is a commonly utilized marker. However, its limitations have prompted alternative biomarker exploration, such as eosinophil-derived neurotoxin (EDN).

Objective

This research was conducted over 24 weeks on 56 patients with severe asthma treated with mepolizumab, reslizumab, and dupilumab. We aimed to evaluate the clinical significance of blood eosinophil count and their potential, including those of blood EDN levels and urine EDN values as biomarkers for predicting treatment response.

Methods

The analysis encompassed examining correlations between biomarkers and clinical features, in

SUBMITTER: Kang YR 

PROVIDER: S-EPMC11784766 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature