Touch-evoked traveling waves establish a translaminar spacetime code.

ABSTRACT: Linking sensory-evoked traveling waves to underlying circuit patterns is critical to understanding the neural basis of sensory perception. To form this link, we performed simultaneous electrophysiology and two-photon calcium imaging through transparent NeuroGrids and mapped touch-evoked traveling waves and underlying microcircuit dynamics. In awake mice, both passive and active whisker touch elicited traveling waves within and across barrels, with a fast early component followed by a late wave that lasted hundreds of milliseconds poststimulus. Notably, late waves were modulated by perceived value and predicted behavioral choice in a two-whisker discrimination task. We found that the late wave feature was (i) modulated by motor feedback, (ii) differentially engaged a sparse ensemble reactiv

SUBMITTER: Gonzales DL 

PROVIDER: S-EPMC11784861 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature