The Role of Serum Free Fatty Acids in Endothelium-Dependent Microvascular Function.

ABSTRACT:

Background

Elevated serum free fatty acid (FFA) concentration is associated with insulin resistance and is a hallmark of metabolic syndrome. A pathological feature of insulin resistance is impaired endothelial function.

Objective

To investigate the effect of FFA reduction with either acipimox, a nicotinic acid derivative that impairs lipolysis, or salsalate, a salicylate that reduces basal and inflammation-induced lipolysis, on insulin-mediated endothelium-dependent vasodilation.

Methods

This was a post hoc, combined analysis of two randomised, double-blind, placebo-controlled crossover trials. Sixteen subjects were recruited (6 with metabolic syndrome and 10 controls) and randomised to acipimox 250 mg orally every 6 h for 7 days or placebo. Nineteen subjects were rec

SUBMITTER: Sullivan AE 

PROVIDER: S-EPMC11784902 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature