Functional variability of Nef in antagonizing SERINC5 during acute to chronic HIV-1 infection.

ABSTRACT:

Objective

The ability of HIV-1 Nef to counteract the host restriction factor SERINC5 and enhance virion infectivity has been well established. However, the impact of long-term within-host Nef evolution on this antagonistic capability remains unclear.

Design

Analysis of longitudinal activity of Nef in antagonizing SERINC5.

Methods

We investigated the downregulation activity of Nef against SERINC5 at different stages of infection by analyzing the cognate transmitted/founder, set point, and/or chronic Nef isolates from a cohort of 19 people with either subtype B or C HIV-1.

Results

The Nef isolates from different stages exhibited varying abilities to antagonize SERINC5. Long-term evolution resulted in mutations accumulated in Nef and a decline of Nef-mediated SERI

SUBMITTER: Li W 

PROVIDER: S-EPMC11784911 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature