SLAMF6 enables efficient attachment, synapse formation, and killing of HIV-1-infected CD4⁺ T cells by virus-specific CD8⁺ T cells.

ABSTRACT: Efficient recognition and elimination of HIV-1-infected CD4⁺ T cells by cytotoxic CD8⁺ T cells (CTLs) require target cell engagement and the formation of a well-organized immunological synapse. Surface proteins belonging to the SLAM family are known to be crucial for stabilizing the immunological synapse and regulating antiviral responses during lymphotropic viral infections. In the context of HIV-1, there have been reports of SLAMF6 down-regulation in HIV-1-infected CD4⁺ T cells; however, the significance of this modulation for CTL function remains unclear. In this investigation, we used CTL lines from People living with HIV (PLWH) to examine the impact of SLAMF6 blockade on three pivotal processes: (1) the formation of CD8⁺-CD4⁺ T-ce

SUBMITTER: Monel B 

PROVIDER: S-EPMC11785116 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature