Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors.

ABSTRACT: A key challenge in cancer research is to identify the secreted factors that contribute to tumor cell survival. Nowhere is this more evident than in Hodgkin lymphoma, where malignant Hodgkin Reed Sternberg (HRS) cells comprise only 1-5% of the tumor mass, the remainder being infiltrating immune cells that presumably are required for the survival of the HRS cells. Until now, there has been no way to characterize the complex Hodgkin lymphoma tumor microenvironment at genome scale. Here, we performed genome-wide transcriptional profiling with spatial and single-cell resolution. We show that the neighborhood surrounding HRS cells forms a distinct niche involving 31 immune and stromal cell types and is enriched in CD4+ T cells, myeloid and follicular dendritic cells, while being depleted of plas

SUBMITTER: Shanmugam V 

PROVIDER: S-EPMC11785141 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature