Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin.

ABSTRACT:

Background

The collagen receptor Endo180 participates in extracellular matrix remodeling by clearing the pericellular environment and recognizing and internalizing collagen degradation products. In photoaged skin, Endo180 expression in fibroblasts is decreased, and collagen fragments accumulate in the pericellular environment, leading to a decrease in type I collagen production and an increase in matrix metalloproteinase 1 production. This suggests that a decrease in Endo180 production may promote wrinkle formation by decreasing the dermal collagen fibril volume. Therefore, this study aimed to identify materials that promote Endo180 production in vitro and investigate whether promoting Endo180 production could prevent and improve wrinkles in vivo.

Methods

Endo180 gene expres

SUBMITTER: Iwahashi H 

PROVIDER: S-EPMC11785151 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature