S100A9 induces tissue remodeling of human nasal epithelium in chronic rhinosinusitis with nasal polyp.

ABSTRACT:

Background

Chronic inflammation triggers tissue remodeling in human nasal epithelial (HNE) cells. S100A9, a protein secreted by inflammatory cells, exhibits potent proinflammatory activity. However, its effect on HNE cell remodeling, such as squamous metaplasia, remains unclear. Therefore, this study aimed to determine the effects and underlying pathways of S100A9 on HNE cell remodeling and investigate its clinical implications in chronic rhinosinusitis (CRS).

Methods

Cultured HNE cells were treated with S100A9. Bulk RNA sequencing was performed to analyze gene ontology (GO). Ingenuity pathway analysis (IPA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were also analyzed. Additionally, immunohistochemistry and multiplex immunofluorescence were performed on tissue sampl

SUBMITTER: Ahn SH 

PROVIDER: S-EPMC11785152 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature