Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses <i>in vitro</i> and <i>in vivo</i>.

ABSTRACT:

Background

Alphaviruses, including chikungunya virus (CHIKV), pose a significant global health threat, yet specific antiviral therapies remain unavailable.

Methods

We evaluated combinations of three oral directly acting antiviral drugs (sofosbuvir (SOF), molnupiravir (MPV), and favipiravir (FAV)), which are approved for other indications, against CHIKV, Semliki Forest virus (SFV), Sindbis virus (SINV), and Venezuelan Equine Encephalitis virus (VEEV) in vitro and in vivo. We assessed antiviral efficacy in human skin fibroblasts and liver cells, as well as in a mouse model of CHIKV-induced arthritis.

Findings

In human skin fibroblasts, synergistic antiviral effects were observed for combinations of MPV + SOF and FAV + SOF against CHIKV, and for FAV + SOF a

SUBMITTER: Verwimp S 

PROVIDER: S-EPMC11785157 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature