The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function.

ABSTRACT: Circadian clocks present throughout the brain and body coordinate diverse physiological processes to support daily homeostasis and respond to changing environmental conditions. The local dependencies within the mammalian clock network are not well defined. We previously demonstrated that the skeletal muscle clock controls transcript oscillations of genes involved in fatty acid metabolism in the liver, yet whether the liver clock also regulates the muscle was unknown. Here, we use hepatocyte-specific Bmal1 KO mice (Bmal1^hep-/-) and reveal that approximately one third of transcriptional rhythms in skeletal muscle are regulated by the liver clock vivo. Treatment of myotubes with serum harvested from Bmal1 ^hep-/- mice inhibited expression of genes involved i

SUBMITTER: Sica V 

PROVIDER: S-EPMC11785164 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature