Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction.

ABSTRACT: Predicting individual vaccine responses remains a significant challenge due to the complexity and variability of immune processes. To address this gap, we developed immunaut, an open-source, data-driven framework implemented as an R package specifically designed for all systems vaccinologists seeking to analyze and predict immunological outcomes across diverse vaccination settings. Leveraging one of the most comprehensive live attenuated influenza vaccine (LAIV) datasets to date - 244 Gambian children enrolled in a phase 4 immunogenicity study - immunaut integrates humoral, mucosal, cellular, transcriptomic, and microbiological parameters collected before and after vaccination, providing an unprecedentedly holistic view of LAIV-induced immunity. Through advanced dimensionalit

SUBMITTER: Hao S 

PROVIDER: S-EPMC11785181 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature