Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis.

ABSTRACT:

Introduction

Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction created by prolonged peripheral and central sensitization plays a role in developing endometriosis-associated CPP. This study investigated how CPP is established using a multiple lesion induction mouse model of endometriosis, as repeated retrograde menstruation is considered underlying endometriosis pathogenesis.

Methods

We generated endometriosis-like lesions by injecting endometrial tissue fragments into the peritoneal cavity in mice. The mice received a single (1x) or multiple inductions (6x) to simulate recurrent retrograde menstruation. Les

SUBMITTER: Harvey ME 

PROVIDER: S-EPMC11785222 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature