Simultaneous Confidence Regions for Image Excursion Sets: a Validation Study with Applications in fMRI.

ABSTRACT: Functional Magnetic Resonance Imaging (fMRI) is commonly used to localize brain regions activated during a task. Methods have been developed for constructing confidence regions of image excursion sets, allowing inference on brain regions exceeding non-zero activation thresholds. However, these methods have been limited to a single predefined threshold and brain volume data, overlooking more sensitive cortical surface analyses. We present an approach that constructs simultaneous confidence regions (SCRs) which are valid for all possible activation thresholds and are applicable to both volume and surface data. This approach is based on a recent method that constructs SCRs from simultaneous confidence bands (SCBs), obtained by using the bootstrap on 1D and 2D images. To extend this method to

SUBMITTER: Qin J 

PROVIDER: S-EPMC11785249 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature