Spatial Heterogeneity and Subtypes of Functional Connectivity Development in Youth.

ABSTRACT: The brain functional connectome development is fundamental to neurocognitive growth in youth. While brain age prediction has been widely used to assess connectome development at the individual level, traditional approaches providing a global index overlook the spatial variability and inter-individual heterogeneity of functional connectivity (FC) development across the cortex. In this study, we introduced a regional brain development index to assess spatially fine-grained FC development. We examined the spatial variability of FC development and stratified individuals into subtypes with distinct patterns of spatial heterogeneity in region-wise FC development across the cortex through clustering. An evaluation conducted on a sample of youths aged 8-23 years using fMRI data from the Philadelph

SUBMITTER: Li H 

PROVIDER: S-EPMC11785253 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature